We have studied the effects of ozone ...

Oxidative stress plays an important role in the pathophysiology of emphysema through activation of proteases and tissue apoptosis. We have studied the effects of ozone, exposing BALB / C mice or one 3-hour exposure or multiple impact on

3 or 6 weeks, with two 3-s exposures per week. Compared to air exposed mice, the increase in neutrophils in bronchoalveolar

washing liquid and pneumonia rate was highest in mice at 3 and 6 weeks. Lung volumes were increased in the third

6 weeks, the exposed mice, but not one that affected. Alveolar space and the mean linear intercept were increased in 6 - and not three weeks, exposed mice.

Caspase-3 and apoptosis protease activating factor-1 imunoreaktyvnosti was increased in the airways and alveolar epithelium lasix heart and macrophages

3rd, 6-week exposed mice. IL-13, keratinocyte hemoattraktantnyy, caspase-3 and IFN-γ mRNA

increased in 6-week-group that has influence, but hemoksihenazy-1 (HO-1) mRNA decreased. matrix metalloproteinazy-12 (MMP-12) and

caspase-3 protein expression is increased in the lungs 6 weeks, exposed mice. Collagen area increased and decreased epithelial area

in the airway wall in the third 6-week exposure. Effect of ozone mice for 6 weeks caused a chronic inflammatory process of alveolar

extension and damage associated with epithelial apoptosis and increased expression of proteases. . << >>